Didik Setiawan, Nunuk Aries Nurulita, Sudewi Mukaromah Khoirunnisa, Maarten J. Postma
Background The comprehensive effectiveness of the HPV vaccine has been widely acknowledged. However, challenges such as dosing adherence and limited budgets have led to delays in HPV vaccination implementation in many countries. A potential solution to these issues could lie in a one-dose vaccination with an HPV vaccine, as indicated by promising outcomes in multiple studies. Methods In this systematic review and meta-analysis, we examine the comparative effectiveness of the one-dose vaccination with an HPV vaccine against two- and three-dose regimens. Our investigation focuses on clinical efficacy, encompassing the prevention of HPV16, HPV18, and hrHPV infections, HSIL or ASC-H incidence, and CIN2/3 incidence. Results Our analysis suggests that a single-dose HPV vaccine may offer effectiveness on par with two- or three-dose schedules. This conclusion is drawn from its capacity to confer immunogenic protection for at least 8 years of follow-up, coupled with its ability to mitigate infections and pre-cancerous occurrences. Conclusion While our findings underscore the potential of the one-dose vaccination with an HPV vaccine, further research and prolonged study durations are necessary to establish robust evidence supporting this recommendation. As such, continued investigation will be critical for informing vaccination strategies. © 2024 Setiawan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Faculty of Pharmacy, University of Muhammadiyah Purwokerto, Purwokerto, Indonesia; Center for Health Economic Studies, Universitas Muhammadiyah Purwokerto, Purwokerto, Indonesia; Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Department of Pharmacy, Institute Teknologi Sumatera, Lampung Selatan, Indonesia; Unit of Pharmaco-Therapy Epidemiology & Economics (PTE2), Department of Pharmacy, University of Groningen, Groningen, Netherlands; Department of Economics Econometrics & Finance, Faculty of Economics & Business, University of Groningen, Groningen, Netherlands
Research at a Glance
Register to unlock
Topics & SDG Alignment
Register to unlock
Collaboration
Register to unlock
Author Profile (Selected)
Register to unlock
References Overview
Register to unlock
Journal & Source
Register to unlock
Metadata & Integrity
Register to unlock