Dewi Nur Azizah, Adelia Pragesti, M. Aliffheo Ramadhan, Rudi Setiawan, Muhammad Artha Jabatsudewa Maras
Indonesia boasts an extensive range of approximately 9,600 herbal plants, each teeming with natural resources. Notably, heart madeiravine (Andera cordifolia) and Gotu Kola (Centella asiatica) possess properties that promote skin healing in burn injuries. However, the traditional approach of directly applying gauze to burns lacks the capability to address a pivotal factor in skin tissue regeneration. To tackle this issue, our study developed an innovative herbal gauze by combining potent extracts from Centella asiatica and heart madeiravine leaves. This endeavor aims to expedite the intricate process of skin regeneration in both first and second-degree burn victims. The fabrication process involved several meticulous stages, starting with the extraction of leaves through soxhletation and cyclic maceration of 500 g of associated foliage at a 10:1 ratio, using a solution of 70% ethanol. Subsequently, the extracts’ suitability was established through rigorous analysis of phytochemical properties, including flavonoid content, presence of saponins, and tannins. A qualitative evaluation of physical aspects, such as pH, homogeneity, viscosity, and organoleptic properties like texture, aroma, and color, was conducted to ensure the gauze's stability and effectiveness. The resulting herbal gauze, infused with extracts from Centella asiatica and Andera cordifolia, successfully met its objectives. Phytochemical analysis confirmed the presence of desired compounds, and the physical assessment demonstrated stability at pH 5, achieving the intended consistency, texture, smell, color, and structural integrity. These promising findings suggest that this innovative herbal gauze holds potential to enhance skin regeneration in first and second-degree burn victims. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.
Biomedical Engineering Study Program, Institut Teknologi Sumatera, Lampung, South Lampung, Indonesia