Erdyvania Apritrycia, Muslimah Dirayati, Nur Aida Wassi’atu, Rudi Setiawan, Muhammad Artha Jabatsudewa Maras, Endah
Wound healing is an elaborate process that needs careful attention in order to restore tissue integrity properly. The rising costs and potential negative effects of traditional wound-healing procedures have generated interest in researching alternative therapies based on natural resources. The potential of Achatina fulica snail mucus and Clitoria ternatea extract to speed the inflammatory phase of wound healing is investigated in this comprehensive analysis. Snail mucus is antimicrobial, promotes tissue interaction, and promotes regeneration and angiogenesis, whereas butterfly pea flower extract is anti-inflammatory and analgesic. They form a promising combination for wound healing. A recent study emphasizes the efficacy of these natural ingredients as well as the benefits of combining them. Researchers have also investigated cutting-edge approaches, such as composite hydrogels, nanoparticles, and 3D-printed scaffolds, to optimize their wound-healing capacity. Furthermore, these natural compounds have shown the potential to reduce inflammation during wound healing by altering macrophage polarisation. Using Achatina fulica snail mucus and Clitoria ternatea extract together boosts angiogenesis, promoting the creation of functional blood vessels and boosting blood flow by activating key signaling pathways. Finally, Achatina fulica snail mucus and Clitoria ternatea extract in wound healing studies show great promise for producing effective and accessible wound care treatments. Their intrinsic characteristics, which are supported by scientific data, have the potential to revolutionize wound healing, giving alleviation and rapid recovery for those with small injuries. Further study and development are required to properly investigate the potential of these natural compounds in accelerating the inflammatory phase of wound healing. This endeavor should spur the development of multifunctional plaster patches that utilize these plentiful materials to promote rapid wound healing. Adopting these long-term treatments has the potential to revolutionize wound care by improving recovery outcomes and boosting access to effective wound-healing technologies. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.
Biomedical Engineering Program, Jurusan Teknologi Produksi Dan Industri, Institut Teknologi Sumatera, Lampung Province, Indonesia
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