Aan Priyanto, Yadi Mulyadi Rohman, Dian Ahmad Hapidin, Dhewa Edikresnha, Khairurrijal Khairurrijal
This study aimed to incorporate virgin coconut oil (VCO) into polyvinylpyrrolidone (PVP) fiber matrix using the rotary force spinning (RFS) method and evaluated their physicochemical properties, antioxidant activity, and release behavior. The PVP/VCO fibers were produced by varying the weight ratios of PVP:VCO of 10:2, 10:3, 10:4, and 10:5. Scanning electron microscopy (SEM) analysis revealed smooth, defect-free, and bead-free PVP/VCO fibers with diameters ranging from (1.28 ± 0.06) to (2.17 ± 0.41) µm. Fourier-transform infrared spectroscopy (FTIR) confirmed the successful loading of VCO into the PVP fiber matrix. X-ray diffraction (XRD) analysis indicated the amorphous nature of the PVP/VCO fibers. Differential scanning calorimetry (DSC) analysis demonstrated that PVP/VCO fibers exhibited higher thermal stability compared to pure PVP and VCO. The antioxidant activity of VCO, with IC50 value of (1.56 ± 0.30) mg mL−1, was not significantly altered by the incorporation of VCO into the PVP fibers. The PVP/VCO fibers exhibited IC50 values ranging from (1.58 ± 0.06) to (2.25 ± 0.09) mg mL−1. The release profile of VCO from the PVP/VCO fibers was influenced by the fiber diameter, with the samples containing weight ratios of 10:4 and 10:5 demonstrating optimal characteristics such as smaller diameter, higher thermal stability, higher antioxidant activity, and prolonged release behavior. This study holds promise for the development of novel oral delivery systems for VCO and contributes to the expanding research on the utilization of fiber structures in food supplement and drug delivery applications. Graphical Abstract: (Figure presented.). © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.
Doctoral Program of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesa No. 10, Jawa Barat, Bandung, 40132, Indonesia; Physics of Electronic Materials Research Group, Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesa No. 10, Jawa Barat, Bandung, 40132, Indonesia; University Center of Excellence – Nutraceutical, Bioscience and Biotechnology Research Center, Institut Teknologi Bandung, Jalan Ganesa No. 10, Jawa Barat, Bandung, 40132, Indonesia; Department of Physics, Faculty of Science, Institut Teknologi Sumatera, Jalan Terusan Ryacudu, Lampung Selatan, Lampung, 35365, Indonesia
Research at a Glance
Register to unlock
Topics & SDG Alignment
Register to unlock
Collaboration
Register to unlock
Author Profile (Selected)
Register to unlock
References Overview
Register to unlock
Journal & Source
Register to unlock
Metadata & Integrity
Register to unlock