Efa Latiffah, Asti Sawitri, Bertolomeus Haryanto Agung, Dian Ahmad Hapidin, Dhewa Edikresnha, Elfahmi Elfahmi, Khairurrijal Khairurrijal
Evaluating Ageratum conyzoides L. (bandotan) weed potential, as a natural antibacterial agent that can be used in the biomedical fields, is the objective of this study. Bandotan leaves extract (BLE) loaded PVP/CA nanofibers were fabricated using an electrospinning technique. The resulting PVP/CA/BLE nanofibers exhibit a pure fibers morphology, with average fibers diameter range of 145–346 nm. Fourier transform infrared analysis demonstrates similarities in the spectra of PVP/CA/BLE nanofibers and pure BLE, confirming the effective loading of BLE into the nanofiber matrix. The nanofibers composed of PVP/CA/BLE exhibit significant antibacterial efficacy against both Staphylococcus aureus and Pseudomonas aeruginosa, ranging from 5 to 71 ( × 10−2 %mg−1), and a high swelling degree of 786%. PVP/CA/BLE nanofibers also exhibit two extract release profiles, burst and sustained release, with a cumulative release of 18–39%. These characteristics make PVP/CA/BLE nanofibers suitable for use as wound dressings, as they can inhibit bacterial growth, absorb wound exudate, and load drug molecules. © 2024 The Authors
Physics and Technology of Advanced Materials, Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung, 40132, Indonesia; Department of Biological Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung, 40132, Indonesia; University Center of Excellence – Nutraceutical, Bioscience and Biotechnology Research Center, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung, 40132, Indonesia; Department of Physics, Faculty of Science, Institut Teknologi Sumatera, Jalan Terusan Ryacudu, Lampung, 35365, Indonesia