Derina Paramitasari, Okta Amelia, Karjawan Pudjianto, Musa Musa, Banon Rustiaty, Arni Supriyanti, Dyah Primarini Meidiawati, Okta Nama Putra, Yanuar Sigit Pramana, Yassaroh Yassaroh, Frita Yuliati, Jatmiko Eko Witoyo, Untia Kartika Sari
Hydroxypropyl cellulose (HPC) is a versatile cellulose ether with two standardized forms: highly substituted (H-HPC), which is water-soluble and thermoresponsive, and low-substituted (L-HPC), which is insoluble but swellable. This systematic review with bibliometric analysis aimed to map the global HPC research landscape (2005–2024), focusing on publication trends, research impact, and thematic directions. Original research articles and conference proceedings indexed in Scopus were included, while reviews and non-research items were excluded. The database was searched on 7 July 2025 using predefined strategies and analyzed using Excel for descriptive statistics and VOSviewer for network visualization. Risk of bias assessment was not applicable; data accuracy was ensured through duplicate removal and the use of standardized bibliometric indicators. A total of 1273 H-HPC and 92 L-HPC publications were analyzed. H-HPC research dominates multidisciplinary applications in drug delivery, 3D printing, thermochromic, and energy materials, whereas L-HPC remains focused on pharmaceutical disintegration and binding. Nevertheless, the field is constrained by reliance on commercial grades and a narrow application focus, leaving broader material innovations underexplored. HPC is positioned as a strategic polysaccharide derivative with expanding translational potential. Future studies should emphasize greener synthesis, advanced functionalization, and industrial scale-up. Funding: Supported by BRIN. Systematic review registration: INPLASY202590019. © 2025 by the authors.
Research Center for Process Technology, National Research and Innovation Agency (BRIN), Bacharuddin Jusuf Habibie Science and Technology Park, South Tangerang, 15314, Indonesia; Department of Agroindustrial Technology, Faculty of Industrial Technology, Institut Teknologi Sumatera (ITERA), South Lampung, 35365, Indonesia; Directorate for Laboratory Management, Research Facilities, and Science and Technology Park, National Research and Innovation Agency (BRIN), Iskandar Zulkarnain Science and Technology Park, South Lampung, 35361, Indonesia; Research Center for Mineral Technology, National Research and Innovation Agency (BRIN), Iskandar Zulkarnain Science and Technology Park, South Lampung, 35361, Indonesia; Research Center for Polymer Technology, National Research and Innovation Agency (BRIN), Bacharuddin Jusuf Habibie Science and Technology Park, South Tangerang, 15314, Indonesia; Department of Pharmacy, Faculty of Science, Institut Teknologi Sumatera (ITERA), South Lampung, 35365, Indonesia
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