David Septian Sumanto Marpaung, Ayu Oshin Yap Sinaga
The four transcription factors Oct4, Sox2, Klf4 and c-Myc are highly expressed in embryonic stem cells (ESC) and their overexpression can induce pluripotency, an ability to differentiate into all cell types of an organism. The ectopic expression such transcription factors could reprogram somatic stem cells to be induced pluripotency stem cells (iPSC), an embryonic stem cells-like. The production of recombinant pluripotency factors gain interests due to the high demand from the generation of induced pluripotent stem cells in regenerative medical therapy recently. The focus of review is to demonstrate the recent advances in recombinant pluripotency factor production using various hosts. © 2020 KIPMI.
Department of Biosystems Engineering, Institut Teknologi Sumatera, South Lampung, 35365, Indonesia; Department of Biology, Institut Teknologi Sumatera, South Lampung, 35365, Indonesia