CD59: Biological function and its potential for drug target action

Sarmoko; Monica Ramadhanti; Nur Ayunie Zulkepli

doi:10.1016/j.genrep.2023.101772

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CD59: Biological function and its potential for drug target action

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Sarmoko, Monica Ramadhanti, Nur Ayunie Zulkepli

2023 Gene Reports Vol. 31 Review Cited by 3 SDG 3SDG 17

Abstract

CD59 is a major inhibitor of membrane attack complex (MAC) formation, which is anchored to the cell membrane by glycosylphosphatidylinositol (GPI). The protein is widely expressed in most human tissues. Several studies have reported the involvement of CD59 with several diseases such as paroxysmal nocturnal hemoglobinuria (PNH), cancer, peripheral demyelination, multiple sclerosis, diabetes mellitus, and viral infections. Herein, we summarized the biological structure and expression pattern of CD59, and its biological function, and focused on discussing the involvement of CD59 in several diseases and its potential for therapeutic use. © 2023 Elsevier Inc.

Affiliations

Department of Pharmacy, Sumatera Institute of Technology, South Lampung, Lampung, Indonesia; Department of Pharmacy, Faculty of Health Science, Jenderal Soedirman University, Central Java, Purwokerto, 53123, Indonesia; Centre for Medical Laboratory Technology Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam Campus, Selangor, 42300, Malaysia

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