Halida Rahmi Luthfianti, William Xaveriano Waresindo, Dhewa Edikresnha, Agus Chahyadi, Tri Suciati, Fatimah Arofiati Noor, Khairurrijal Khairurrijal
Andrographolide (AG) is one of the compounds in Andrographis paniculata, which has a high antibacterial activity. This paper reports the freeze-thaw method’s use to synthesize polyvinyl alcohol (PVA) hydrogels loaded with AG and its characterization. From the morphological examination, the porosity of the PVA/AG hydrogel was found to increase with the increasing AG concentration. The swelling degree test revealed that the hydrogels’ maximum swelling degrees were generally greater than 100%. The composite hydrogel with the highest fraction of andrographolide (PAG-4) showed greater weight loss than the hydrogel without AG (PAG-0). The molecular interaction between PVA and AG resulted in the narrowing of the band attributed to the O-H and C═O stretching bonds and the emergence of an amorphous domain in the composite hydrogels. The loading of AG disrupted the formation of hydroxyl groups in PVA and interrupted the cross-linking between PVA chains, which lead to the decrease of the compression strength and the crystallinity increased with increasing AG. The antibacterial activity of the composite hydrogel increased with increasing AG. The PAG-4 hydrogel had the highest antibacterial activity of 37.9 ± 4.6b %. Therefore, the PVA/AG hydrogel has the potential to be used as an antibacterial device. © 2023 The Authors. Published by American Chemical Society.
Doctoral Program of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha, 10, Jawa Barat, Bandung, 40132, Indonesia; Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha, 10, Jawa Barat, Bandung, 40132, Indonesia; Bioscience and Biotechnology Research Center, University Center of Excellence for Nutraceuticals, Institut Teknologi Bandung, Jalan Ganesa 10, Jawa Barat, Bandung, 40132, Indonesia; Department of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung, Jalan Ganesha 10, Jawa Barat, Bandung, 40132, Indonesia; Department of Physics, Faculty of Science, Institut Teknologi Sumatera, Jalan Terusan Ryacudu, Lampung Selatan, 35365, Indonesia
Research at a Glance
Register to unlock
Topics & SDG Alignment
Register to unlock
Collaboration
Register to unlock
Author Profile (Selected)
Register to unlock
References Overview
Register to unlock
Journal & Source
Register to unlock
Metadata & Integrity
Register to unlock